Answers:
I.

1. Thyrotropin Releasing Hormone
2. Thyrotropin Releasing Hormone Stimulation Test
3. Hypothalamus
4. TRH
5. Anterior Pituitary
6. Hyperthyroidism
7. Hypothalamus
8. Thyrotropin Releasing Factor (TRF), thyroliberin or protilerin
9. Thyrotropin Releasing Factor
10. Thyrotropin Releasing Hormone Stimulation Test

II.

1. The casuse of the disease is lack of iodine, and this causes Goiter also called Bronchocele. The patient may be given an iodine supplement orally. This may lead to goiter reduction size. And by surgical removal.

TRH QUIZ

__________1. Transcribe TRH.
__________2. It is the test for TRH.
__________3. Endorine gland that releases TRH.
__________4. Its Function is to control TSH production.
__________5. Endocrine gland that releases TSH.
__________6. Increase stimulation of TRH may cause this disease.
__________7. Regulates the TRH production.
__________8. Other name of TRH.
__________9. Transcribe TRF.
__________10. It is the confirmatory test for primary hyperthyroidism.

11-20

A 30 year old woman, has an enlarge neck and protruding eyes. She reported about swallowing difficulties from compression of the esophagus, neck vein distention and dizziness when the arms are raised above the head. She tested for iodine test and the doctor's found out that she lacks of iodine.

What is the probable cause of the disease? What methods can be done to treat this disease?

Thyrotropin Releasing Hormone (TRH)

Thyrotropin Releasing Hormone (TRH) also called Thyrotropin Releasing Factor (TRF), thyroliberin or protilerin. Its function is to control the release of thyroid stimulating hormone (TSH) which produces thyroid hormones responsible for the growth of thyroid gland by the anterior pituitary.

Thyrotropin Releasing Hormone Stimulation Test

It is use to monitor patients who have hyperthyroidism or hypothyroidism. it is use to detect residual TSH stores in the pituitary gland

. It is the confirmatory test for primary hyperthyroidism. it is also use to detect thyroid hormone resistance syndromes. it can differentiate secondary hypothyroidism from tertiary hypothyroidism. WheN a TRH is injected on a patient with secondary hypothyroidism, the TSH level will not increase but when TRH is injected with patient that suffers with tertiary hypothyroidism it will respond to TRH stimulation.


Specimen:
Red Tap or EDTA
Intravenous 200 – 500 ug of synthetic TRH
specimen free from lipemia and hemolysis

Procedure:

>The test is performed in the morning, with a overnight fasting.

>Samples for TSH are drawn before 30 minutes and 60 minutes before the administration of TRH.

>TRH is injected intravenously.

Side Effects And Risks:

It may cause nausea, vomiting and urge to urinate. It may also cause constriction of the blood vessel which can lead to hemorrhage in patients with pre existing pituitary tumors.



Reference:

http://www.clinlabnavigator.com/Tests/ThyrotropinRelHormoneStimTest.html

http://en.wikipedia.org/wiki/Thyrotropin-releasing_hormone

Clinical Chemistry Principles, Procedures, Correlations
by: Michael L. Bishop, Janet L. Duben-Engelkirk and Edward P. Fody