Thyrotropin Releasing Hormone (TRH) also called Thyrotropin Releasing Factor (TRF), thyroliberin or protilerin. Its function is to control the release of thyroid stimulating hormone (TSH) which produces thyroid hormones responsible for the growth of thyroid gland by the anterior pituitary.
Thyrotropin Releasing Hormone Stimulation Test
It is use to monitor patients who have hyperthyroidism or hypothyroidism. it is use to detect residual TSH stores in the pituitary gland. It is the confirmatory test for primary hyperthyroidism. it is also use to detect thyroid hormone resistance syndromes. it can differentiate secondary hypothyroidism from tertiary hypothyroidism. WheN a TRH is injected on a patient with secondary hypothyroidism, the TSH level will not increase but when TRH is injected with patient that suffers with tertiary hypothyroidism it will respond to TRH stimulation.
Specimen:
Red Tap or EDTA
Intravenous 200 – 500 ug of synthetic TRH
specimen free from lipemia and hemolysis
Procedure:
>The test is performed in the morning, with a overnight fasting.
>Samples for TSH are drawn before 30 minutes and 60 minutes before the administration of TRH.
>TRH is injected intravenously.
Side Effects And Risks:
It may cause nausea, vomiting and urge to urinate. It may also cause constriction of the blood vessel which can lead to hemorrhage in patients with pre existing pituitary tumors.
Reference:
http://www.clinlabnavigator.com/Tests/ThyrotropinRelHormoneStimTest.html
http://en.wikipedia.org/wiki/Thyrotropin-releasing_hormone
Clinical Chemistry Principles, Procedures, Correlations
by: Michael L. Bishop, Janet L. Duben-Engelkirk and Edward P. Fody
the post was short yet so informative. good.
ReplyDeleteGood points:
ReplyDelete1. Original layout
2. Original post.
Suggestions:
1. Color is too drab.
2. Include other tests (stimulation tests)
Create a link from the URL to the site itself.
ReplyDeleteNice template!
ReplyDeleteyour post is good, the meaning was clear. it will help the reader to understand the topic easily...
keep it up...=)
short but meaningful. add more some info about TRH to make it more interesting and detailed. haha.
ReplyDeletevery nice background.... your post is very short yet informative. but kindly change the color of your font because it is somehow difficult for me to read it...
ReplyDeleteA good post,though it short, it has has the basic information to understand the topic.
ReplyDelete: Nice layout, violin? haha! The post is too short kindly add some additional information so that the reader can easily cope and comprehend your topic.
ReplyDeletehey julz.
ReplyDeleteyour work is good,like your background
keep it up!
have fun,,ehe
comment me plz..
Hello, Julius. I like your post. Very informative. However, under the procedure, procedure 2, you said, "Samples for TSH are drawn before 30 minutes and 60 minutes before the administration of TRH."
ReplyDeleteDid you really mean that, or did you mean 30 min."before" and 60 min. "after" the administration of TRH? Here lies my confusion on the matter, unless the patient is under medication for hypothyroidism, TSH value should be stable and should not change in a matter of 30 minutes, correct? But, if the patient is under medication, then the 30 and 60 minutes before the administration of TRH would make sense to me. Please enlighten me.
BTW, keep posting these types of topics. It’s a great mode to inform and educate us all. I like it because I read it without getting bombarded with so much information all at once.
Tasha